Analysis of C-reactive Protein as an Inflammation Biomarker in Type-2 Diabetes Mellitus Patients at Minahasa, North Sulawesi, Indonesia

Diana Shintawati Purwanto^1,2, Sylvia Ritta Marunduh³, Stefana Helena Margaretha Kaligis¹

Corresponding Author: Diana Shintawati Purwanto

¹Department of Biochemistry, Faculty of Medicine, Sam Ratulangi University, Manado, Indonesia

²Department of Clinical Laboratory, R. D Kandou Central General Hospital, Manado, Indonesia

³Department of Physiology, Faculty of Medicine, Sam Ratulangi University, Manado, Indonesia

International Journal of Diabetes and Endocrinology, Volume 8, Issue 4, December 2023

Pages: 50-53

Received: Sep. 16, 2023

Accepted: Oct. 09, 2023

Published: Oct. 28, 2023

DOI: 10.11648/j.ijde.20230804.12

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Abstract

C-reactive protein is a non-specific acute phase reactant produced by the liver and endothelial cells. Inflammation or acute infections cause a rise in C-reactive protein, which can be measured to determine the risk of cardiovascular disease. The hs-CRP test can detect CRP at lower concentrations because it is more sensitive, making it more effective than conventional CRP testing methods. This study aimed determine the relationship between hs-CRP levels and fasting blood glucose, and to examine whether there were differences in hs-CRP levels in patients with type-2 diabetes mellitus with or without hypertension, in Minahasa, North Sulawesi, Indonesia. A total of 123 diabetes mellitus patients were included in this cross-sectional study. Subjects were tested for blood pressure, body mass index, fasting blood glucose, and hs-CRP levels. The correlation between hs-CRP and fasting blood glucose had a correlation coefficient (r) 0.404 and p-value 0.000 (<0.05). The average hs-CRP level in type-2 diabetes mellitus patients with hypertension was 148.8 ± 24.9 mg/dL and 55.1 ± 54.0 mg/dL without hypertension. In conclusion, there was a significant relationship between hs-CRP and fasting blood glucose levels, and type-2 diabetes mellitus patients with hypertension also had greater hs-CRP levels than those without hypertension. This suggests that hs-CRP can be used to evaluate a diabetic patient's risk for cardiovascular disease.

Keywords

Diabetes Mellitus, Fasting Blood Glucose, hs-CRP

To cite this article

Diana Shintawati Purwanto, Sylvia Ritta Marunduh, Stefana Helena Margaretha Kaligis. (2023). Analysis of C-reactive Protein as an Inflammation Biomarker in Type-2 Diabetes Mellitus Patients at Minahasa, North Sulawesi, Indonesia . International Journal of Diabetes and Endocrinology, 8(4), 50-53. https://doi.org/10.11648/j.ijde.20230804.12

Copyright © 2023 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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