High Lipoprotein (a) Concentration Is Associated with Diabetic Nephrophaty

Meutia Atika Faradilla; Karina Shasri Anastasya; Yohana; Meiyanti; Andira Larasari; Daniella Satyasari; Endrico Xavierees Tungka

doi:doi:10.11648/j.ijde.20230803.11

High Lipoprotein (a) Concentration Is Associated with Diabetic Nephrophaty

Meutia Atika Faradilla, Karina Shasri Anastasya, Yohana, Meiyanti, Andira Larasari, Daniella Satyasari, Endrico Xavierees Tungka

Published in International Journal of Diabetes and Endocrinology (Volume 8, Issue 3)

Received: 6 August 2023 Accepted: 4 September 2023 Published: 13 September 2023

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Abstract

Aims: Lipoprotein (a) [Lp(a)] has been well recognized as a risk factor for both micro and macrovascular complications in diabetes, due to its atherogenic effects. Studies suggested that serum lipoprotein (a) [Lp(a)] concentration may take part in the aggravation of diabetic nephropathy. Accumulating evidence suggests that higher serum Lp(a) may be associated with impaired renal function in populations. Therefore this study comprehensively evaluates the association between Lipoprotein (a) and diabetic nephropathy in patients with type 2 diabetes mellitus. Methods: One hundred subjects (50 with diabetic nephrophaty and 50 type 2 diabetes mellitus without nephrophaty) were studied. The examination used blood serum where lipoprotein a used the ELISA method. Nonpara- metric Mann–Whitney U-tests were used to compare the levels of lipoprotein a in diabetic nephrophaty and Type 2 DM without diabetic nephropathy. Results: Lipoprotein a in the diabetic nephropathy group was higher when compared to the type 2 DM group without nephropathy (OR = 2.8; 95%; CI = 1.84-12.07). Conclution: High lipoprotein (a) concentration are associated with diabetic nephrophaty. Lipoprotein may reflect chronic underlying pathophysiological processes involved in development of complications of T2DM and serum Lp(a) can be considered as a promising predictive factor for the diagnosis of earlier diabetic nephropathy.

Published in	International Journal of Diabetes and Endocrinology (Volume 8, Issue 3)
DOI	10.11648/j.ijde.20230803.11
Page(s)	37-41
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Lipoprotein (a), Diabetic Nephrophaty, Type 2 Diabetes Mellitus

References

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APA Style

Meutia Atika Faradilla, Karina Shasri Anastasya, Yohana, Meiyanti, Andira Larasari, et al. (2023). High Lipoprotein (a) Concentration Is Associated with Diabetic Nephrophaty. International Journal of Diabetes and Endocrinology, 8(3), 37-41. https://doi.org/10.11648/j.ijde.20230803.11

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ACS Style

Meutia Atika Faradilla; Karina Shasri Anastasya; Yohana; Meiyanti; Andira Larasari, et al. High Lipoprotein (a) Concentration Is Associated with Diabetic Nephrophaty. Int. J. Diabetes Endocrinol. 2023, 8(3), 37-41. doi: 10.11648/j.ijde.20230803.11

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AMA Style

Meutia Atika Faradilla, Karina Shasri Anastasya, Yohana, Meiyanti, Andira Larasari, et al. High Lipoprotein (a) Concentration Is Associated with Diabetic Nephrophaty. Int J Diabetes Endocrinol. 2023;8(3):37-41. doi: 10.11648/j.ijde.20230803.11

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@article{10.11648/j.ijde.20230803.11,
  author = {Meutia Atika Faradilla and Karina Shasri Anastasya and Yohana and Meiyanti and Andira Larasari and Daniella Satyasari and Endrico Xavierees Tungka},
  title = {High Lipoprotein (a) Concentration Is Associated with Diabetic Nephrophaty},
  journal = {International Journal of Diabetes and Endocrinology},
  volume = {8},
  number = {3},
  pages = {37-41},
  doi = {10.11648/j.ijde.20230803.11},
  url = {https://doi.org/10.11648/j.ijde.20230803.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijde.20230803.11},
  abstract = {Aims: Lipoprotein (a) [Lp(a)] has been well recognized as a risk factor for both micro and macrovascular complications in diabetes, due to its atherogenic effects. Studies suggested that serum lipoprotein (a) [Lp(a)] concentration may take part in the aggravation of diabetic nephropathy. Accumulating evidence suggests that higher serum Lp(a) may be associated with impaired renal function in populations. Therefore this study comprehensively evaluates the association between Lipoprotein (a) and diabetic nephropathy in patients with type 2 diabetes mellitus. Methods: One hundred subjects (50 with diabetic nephrophaty and 50 type 2 diabetes mellitus without nephrophaty) were studied. The examination used blood serum where lipoprotein a used the ELISA method. Nonpara- metric Mann–Whitney U-tests were used to compare the levels of lipoprotein a in diabetic nephrophaty and Type 2 DM without diabetic nephropathy. Results: Lipoprotein a in the diabetic nephropathy group was higher when compared to the type 2 DM group without nephropathy (OR = 2.8; 95%; CI = 1.84-12.07). Conclution: High lipoprotein (a) concentration are associated with diabetic nephrophaty. Lipoprotein may reflect chronic underlying pathophysiological processes involved in development of complications of T2DM and serum Lp(a) can be considered as a promising predictive factor for the diagnosis of earlier diabetic nephropathy.},
 year = {2023}
}

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TY  - JOUR
T1  - High Lipoprotein (a) Concentration Is Associated with Diabetic Nephrophaty
AU  - Meutia Atika Faradilla
AU  - Karina Shasri Anastasya
AU  - Yohana
AU  - Meiyanti
AU  - Andira Larasari
AU  - Daniella Satyasari
AU  - Endrico Xavierees Tungka
Y1  - 2023/09/13
PY  - 2023
N1  - https://doi.org/10.11648/j.ijde.20230803.11
DO  - 10.11648/j.ijde.20230803.11
T2  - International Journal of Diabetes and Endocrinology
JF  - International Journal of Diabetes and Endocrinology
JO  - International Journal of Diabetes and Endocrinology
SP  - 37
EP  - 41
PB  - Science Publishing Group
SN  - 2640-1371
UR  - https://doi.org/10.11648/j.ijde.20230803.11
AB  - Aims: Lipoprotein (a) [Lp(a)] has been well recognized as a risk factor for both micro and macrovascular complications in diabetes, due to its atherogenic effects. Studies suggested that serum lipoprotein (a) [Lp(a)] concentration may take part in the aggravation of diabetic nephropathy. Accumulating evidence suggests that higher serum Lp(a) may be associated with impaired renal function in populations. Therefore this study comprehensively evaluates the association between Lipoprotein (a) and diabetic nephropathy in patients with type 2 diabetes mellitus. Methods: One hundred subjects (50 with diabetic nephrophaty and 50 type 2 diabetes mellitus without nephrophaty) were studied. The examination used blood serum where lipoprotein a used the ELISA method. Nonpara- metric Mann–Whitney U-tests were used to compare the levels of lipoprotein a in diabetic nephrophaty and Type 2 DM without diabetic nephropathy. Results: Lipoprotein a in the diabetic nephropathy group was higher when compared to the type 2 DM group without nephropathy (OR = 2.8; 95%; CI = 1.84-12.07). Conclution: High lipoprotein (a) concentration are associated with diabetic nephrophaty. Lipoprotein may reflect chronic underlying pathophysiological processes involved in development of complications of T2DM and serum Lp(a) can be considered as a promising predictive factor for the diagnosis of earlier diabetic nephropathy.
VL  - 8
IS  - 3
ER  -

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Author Information

Meutia Atika Faradilla

Department of Biochemistry, Faculty of Medicine, Universitas Trisakti, Jakarta, Indonesia
Karina Shasri Anastasya

Department of Nutrition, Faculty of Medicine, Universitas Trisakti, Jakarta, Indonesia
Yohana

Department of Biochemistry, Faculty of Medicine, Universitas Trisakti, Jakarta, Indonesia
Meiyanti

Department of Pharmacology and Medical Pharmacy, Faculty of Medicine, Universitas Trisakti, Jakarta, Indonesia
Andira Larasari

Department of Neurology, Faculty of Medicine, Universitas Trisakti, Jakarta, Indonesia
Daniella Satyasari

Department of Phsyciatry, Faculty of Medicine, Universitas Trisakti, Jakarta, Indonesia
Endrico Xavierees Tungka

Department of Biochemistry, Faculty of Medicine, Universitas Trisakti, Jakarta, Indonesia

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APA Style

Meutia Atika Faradilla, Karina Shasri Anastasya, Yohana, Meiyanti, Andira Larasari, et al. (2023). High Lipoprotein (a) Concentration Is Associated with Diabetic Nephrophaty. International Journal of Diabetes and Endocrinology, 8(3), 37-41. https://doi.org/10.11648/j.ijde.20230803.11

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ACS Style

Meutia Atika Faradilla; Karina Shasri Anastasya; Yohana; Meiyanti; Andira Larasari, et al. High Lipoprotein (a) Concentration Is Associated with Diabetic Nephrophaty. Int. J. Diabetes Endocrinol. 2023, 8(3), 37-41. doi: 10.11648/j.ijde.20230803.11

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AMA Style

Meutia Atika Faradilla, Karina Shasri Anastasya, Yohana, Meiyanti, Andira Larasari, et al. High Lipoprotein (a) Concentration Is Associated with Diabetic Nephrophaty. Int J Diabetes Endocrinol. 2023;8(3):37-41. doi: 10.11648/j.ijde.20230803.11

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@article{10.11648/j.ijde.20230803.11,
  author = {Meutia Atika Faradilla and Karina Shasri Anastasya and Yohana and Meiyanti and Andira Larasari and Daniella Satyasari and Endrico Xavierees Tungka},
  title = {High Lipoprotein (a) Concentration Is Associated with Diabetic Nephrophaty},
  journal = {International Journal of Diabetes and Endocrinology},
  volume = {8},
  number = {3},
  pages = {37-41},
  doi = {10.11648/j.ijde.20230803.11},
  url = {https://doi.org/10.11648/j.ijde.20230803.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijde.20230803.11},
  abstract = {Aims: Lipoprotein (a) [Lp(a)] has been well recognized as a risk factor for both micro and macrovascular complications in diabetes, due to its atherogenic effects. Studies suggested that serum lipoprotein (a) [Lp(a)] concentration may take part in the aggravation of diabetic nephropathy. Accumulating evidence suggests that higher serum Lp(a) may be associated with impaired renal function in populations. Therefore this study comprehensively evaluates the association between Lipoprotein (a) and diabetic nephropathy in patients with type 2 diabetes mellitus. Methods: One hundred subjects (50 with diabetic nephrophaty and 50 type 2 diabetes mellitus without nephrophaty) were studied. The examination used blood serum where lipoprotein a used the ELISA method. Nonpara- metric Mann–Whitney U-tests were used to compare the levels of lipoprotein a in diabetic nephrophaty and Type 2 DM without diabetic nephropathy. Results: Lipoprotein a in the diabetic nephropathy group was higher when compared to the type 2 DM group without nephropathy (OR = 2.8; 95%; CI = 1.84-12.07). Conclution: High lipoprotein (a) concentration are associated with diabetic nephrophaty. Lipoprotein may reflect chronic underlying pathophysiological processes involved in development of complications of T2DM and serum Lp(a) can be considered as a promising predictive factor for the diagnosis of earlier diabetic nephropathy.},
 year = {2023}
}

Copy | Download

TY  - JOUR
T1  - High Lipoprotein (a) Concentration Is Associated with Diabetic Nephrophaty
AU  - Meutia Atika Faradilla
AU  - Karina Shasri Anastasya
AU  - Yohana
AU  - Meiyanti
AU  - Andira Larasari
AU  - Daniella Satyasari
AU  - Endrico Xavierees Tungka
Y1  - 2023/09/13
PY  - 2023
N1  - https://doi.org/10.11648/j.ijde.20230803.11
DO  - 10.11648/j.ijde.20230803.11
T2  - International Journal of Diabetes and Endocrinology
JF  - International Journal of Diabetes and Endocrinology
JO  - International Journal of Diabetes and Endocrinology
SP  - 37
EP  - 41
PB  - Science Publishing Group
SN  - 2640-1371
UR  - https://doi.org/10.11648/j.ijde.20230803.11
AB  - Aims: Lipoprotein (a) [Lp(a)] has been well recognized as a risk factor for both micro and macrovascular complications in diabetes, due to its atherogenic effects. Studies suggested that serum lipoprotein (a) [Lp(a)] concentration may take part in the aggravation of diabetic nephropathy. Accumulating evidence suggests that higher serum Lp(a) may be associated with impaired renal function in populations. Therefore this study comprehensively evaluates the association between Lipoprotein (a) and diabetic nephropathy in patients with type 2 diabetes mellitus. Methods: One hundred subjects (50 with diabetic nephrophaty and 50 type 2 diabetes mellitus without nephrophaty) were studied. The examination used blood serum where lipoprotein a used the ELISA method. Nonpara- metric Mann–Whitney U-tests were used to compare the levels of lipoprotein a in diabetic nephrophaty and Type 2 DM without diabetic nephropathy. Results: Lipoprotein a in the diabetic nephropathy group was higher when compared to the type 2 DM group without nephropathy (OR = 2.8; 95%; CI = 1.84-12.07). Conclution: High lipoprotein (a) concentration are associated with diabetic nephrophaty. Lipoprotein may reflect chronic underlying pathophysiological processes involved in development of complications of T2DM and serum Lp(a) can be considered as a promising predictive factor for the diagnosis of earlier diabetic nephropathy.
VL  - 8
IS  - 3
ER  -

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