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The Influencing Factors Associated with Ketosis-Prone Type 2 Diabetes Mellitus: A Syndrome of Diabetes Mellitus
Md Rezaul Karim,
Afsarunnesa Syeda
Issue:
Volume 3, Issue 1, March 2018
Pages:
1-6
Received:
21 February 2018
Accepted:
9 March 2018
Published:
3 April 2018
Abstract: Ketosis-prone diabetes or KPD is an intermediate form of diabetes and is a widespread syndrome. To review the influencing factors of ketosis in type 2 diabetes (T2DK), All patients of ketosis with type 2 diabetes are studied under single entity as the method. In this review, we described the current state of knowledge in regard to Ethnicity, age, sex, family history, infection, obesity, Dyslipidemia, and Hyperglycemia is associated as the influencing factors in Ketosis-Prone Type 2 Diabetes Mellitus.
Abstract: Ketosis-prone diabetes or KPD is an intermediate form of diabetes and is a widespread syndrome. To review the influencing factors of ketosis in type 2 diabetes (T2DK), All patients of ketosis with type 2 diabetes are studied under single entity as the method. In this review, we described the current state of knowledge in regard to Ethnicity, age, s...
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Antidiabetic, Antisickling and Antibacterial Activities of Anacardium occidentale L. (Anacardiaceae) and Zanthoxylum rubescens Planch. Ex Hook (Rutaceae) from DRC
Gédéon Bongo,
Koto-te-Nyiwa Ngbolua,
Colette Ashande,
Benjamin Gbolo,
Claudine Tshiama,
Dorothée Tshilanda,
Damien Tshibangu,
Nadège Ngombe,
Théophile Mbemba,
Pius Mpiana
Issue:
Volume 3, Issue 1, March 2018
Pages:
7-14
Received:
22 February 2018
Accepted:
27 March 2018
Published:
4 May 2018
Abstract: It was recently reported a rare association of two genetic diseases notably sickle cell anemia and diabetes in one patient in the Democratic Republic of the Congo. Both diseases constitute a serious public health problem and have a common denominator that is to make patients susceptible to bacterial infections. Given the difficult and limited management of these diseases, the use of medicinal plants is considered as an effective alternative. Leaves of Anacardium occidentale and Zanthoxylum rubescens collected in the surroundings of University of Kinshasa and Gbadolite in Kinshasa and Nord Ubangi provinces respectively and these plants were selected through a chemo-taxonomic approach while a phytochemical screening was performed using a qualitative approach. Bacterial strains used to assess the antibacterial activity were Staphylococcus aureus and Escherichia coli and mice were used for the antidiabetic activity. The phytochemical screening revealed the presence of tannins, anthocyanins, leucoanthocyanins, flavonoids, bound quinones as well saponins and alkaloids. The aqueous extracts of A. occidentale and Z. rubescens showed an antisickling activity. Only S. aureus was sensitive to A. occidentale where petroleum ether extract (MIC = 125 μg.mL-1) showed a good activity than other extracts and no activity was observed on E. coli. Meanwhile, Z. rubescens showed no antibacterial activity on both strains (MIC = > 500 μg.mL-1). The mean values of blood glucose after 120 minutes in untreated and treated mice were 99.5 ± 7.77mg.dL-1 (0.9% NaCl), 41.6 ± 10.07mg.dL-1 (Glibenclamide 10mg.Kg-1) and 64 ± 13.98mg.dL-1 (methanolic extract of A. occidentale 500mg.Kg-1). These findings show that A. occidentale plant possess an antihyperglycemic activity. To our knowledge, it is for the first time that the antisickling activity of A. occidentale and Z. rubescens is reported thus validating the chemotaxonomic approach used as a criterion of selection of these two plants. It is also for the first time that antidiabetic activity of A. occidentale is reported.
Abstract: It was recently reported a rare association of two genetic diseases notably sickle cell anemia and diabetes in one patient in the Democratic Republic of the Congo. Both diseases constitute a serious public health problem and have a common denominator that is to make patients susceptible to bacterial infections. Given the difficult and limited manag...
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Syndrome Z and Its Association with Obstructive Sleep Apnea
Gulam Hassan,
Waseem Qureshi
Issue:
Volume 3, Issue 1, March 2018
Pages:
15-17
Received:
26 February 2018
Accepted:
16 March 2018
Published:
4 May 2018
Abstract: It is clear that obstructive sleep apnea (OSA) and metabolism syndrome share a similar pathophysilogic milieu that would be expected to increase the risk of cardiovascular disease. In patients with established coronary artery disease, treatment of OSA may confer long term cardiovascular benefits. Prevention of nocturnal hypoxemia, sympathetic activation and pressor surges in addition to reduction of daytime sympathetic activity, blood pressure and insulin resistance by continuous positive airway pressure would improve cardiovascular outcomes in patients with metabolic syndrome.
Abstract: It is clear that obstructive sleep apnea (OSA) and metabolism syndrome share a similar pathophysilogic milieu that would be expected to increase the risk of cardiovascular disease. In patients with established coronary artery disease, treatment of OSA may confer long term cardiovascular benefits. Prevention of nocturnal hypoxemia, sympathetic activ...
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Endocrine Disruptor Compounds (EDC) Effects on Reproduction
Issue:
Volume 3, Issue 1, March 2018
Pages:
18-22
Received:
25 March 2018
Accepted:
12 April 2018
Published:
14 May 2018
Abstract: A large number of industrial chemical products (paints, flame retardants, pharmaceuticals, pesticides) are suspected or proved to act as endocrine disruptor compounds (EDCs). In the present survey of the literature, the main issue is to consider how to classify individual products as EDC or not. In this perspective, the different mechanisms leading to endocrine disruption are described: either by direct interaction with hormone receptors leading to its stimulation or inhibition, or by effect on endogenous hormone concentration through stimulation or inhibition of its synthesis or its degradation, or its binding to transport binding proteins. The present review takes particularly in consideration the effects of EDCs on the endocrine control of Reproduction in human and animals. Indeed, a number of EDCs can act as anti-androgens, anti-estrogens, and steroidogenic enzyme inhibitors that interfere with steroid action or production and thus can alter reproductive health.
Abstract: A large number of industrial chemical products (paints, flame retardants, pharmaceuticals, pesticides) are suspected or proved to act as endocrine disruptor compounds (EDCs). In the present survey of the literature, the main issue is to consider how to classify individual products as EDC or not. In this perspective, the different mechanisms leading...
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