Efficacy of Hydroxychloroquine as an Add on Drug with Basal Insulin, Gliclazide and Metformin in Subjects with Uncontrolled Type 2 Diabetes Mellitus
Abhishek Kumar Chandra,
Sajjad Ahsan,
Prakash Ranjan,
Ajeet Kumar Sinha,
Rajeev Ranjan Kumar
Issue:
Volume 3, Issue 4, December 2018
Pages:
58-62
Received:
25 November 2018
Accepted:
11 December 2018
Published:
7 January 2019
DOI:
10.11648/j.ijde.20180304.11
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Abstract: The aim of the study was to evaluate the clinical safety and efficacy of hydroxychloroquine in subjects with were poorly controlled type 2 diabetes mellitus (T2DM), despite treatment with insulin glargine and a combination of gliclazide and metformin. 105 patients with type 2 DM, mean age 56.84 years and mean body mass index (BMI) 26.30 kg/m2, were enrolled in this multicentre open label trial. They were given hydroxychloroquine 400 mg/day in addition to previous treatment with insulin glargine (≥30 units a day), gliclazide (80 mg a day) and metformin (1000 mg a day) for a period of six months. Hydroxychloroquine 400 mg/day, when added to insulin glargine and the combination of gliclazide and metformin, significantly decreased hemoglobin A1c (HbA1c) at six months from a mean of 8.15±0.24 to a mean of 6.69±0.42 (p<0.0001) and fasting plasma glucose (FPG) at six months from a mean of 209.5 ± 31.23 mg/dl to 115.14 ± 36.94 mg/dl and post prandial plasma glucose (PPG) from a mean of 338.22 ± 31.76 mg/dl to 147.71 ±22.47 mg/dl (p<0.0001). Hydroxychloroquine was well tolerated throughout the study period. The mean dose of insulin glargine decreased during the study from 35.51 ± 9.93 units per day to 20.00 ± 9.6 units/day at six months (p<0.0001). The frequency of insulin glargine injections decreased from a mean of 2.15 ± 0.22/day to 1.18 ± 0.85/day (p<0.0001). In 43 (41%) patients insulin glargine had to be totally stopped. In 13 (12%) patients the dose of gliclazide decreased to 40 mg. Hydroxychloroquine was found to improve glycemic control, when given as a fourth drug (quadruple drug therapy) in addition to insulin and the combination of gliclazide and metformin in patients with type 2 DM. In a significant number of patients, insulin therapy could be stopped, and in the rest the dose of insulin and gliclazide could be reduced.
Abstract: The aim of the study was to evaluate the clinical safety and efficacy of hydroxychloroquine in subjects with were poorly controlled type 2 diabetes mellitus (T2DM), despite treatment with insulin glargine and a combination of gliclazide and metformin. 105 patients with type 2 DM, mean age 56.84 years and mean body mass index (BMI) 26.30 kg/m2, were...
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HIIT and Moderate Intensity Training on the Latest Research Progress of Type 2 Diabetes
Issue:
Volume 3, Issue 4, December 2018
Pages:
63-67
Received:
9 December 2018
Accepted:
25 December 2018
Published:
25 January 2019
DOI:
10.11648/j.ijde.20180304.12
Downloads:
Views:
Abstract: HIIT and moderate intensity training for reducing the effect of blood sugar, blood lipid index in type 2 diabetes are remarkable, but for the improvement of mechanism, it remains to be further research. In this paper, compaired with the mechanism and clinical efficacy of type 2 diabetes , it is pointed out that HIIT has time-saving and efficient characteristics and it is suitable for patients with mild diabetes. Moderate intensity training takes more time and it is suitable for patients with moderate or severe diabetes, providing guidance for the treatment of diabetes mellitus.
Abstract: HIIT and moderate intensity training for reducing the effect of blood sugar, blood lipid index in type 2 diabetes are remarkable, but for the improvement of mechanism, it remains to be further research. In this paper, compaired with the mechanism and clinical efficacy of type 2 diabetes , it is pointed out that HIIT has time-saving and efficient ch...
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