Possibilities of Early Combination Therapy with Sitagliptin and Metformin in the Correction of Metabolic Disorders in Patients with Type 2 Diabetes and Obesity
Ametov Alexander Sergeevich,
Gusenbekova Dinara Gadjimagomedovna,
Butaeva Svetlana Garrievna,
P'yanykh Olga Pavlovna
Issue:
Volume 5, Issue 1, March 2020
Pages:
1-5
Received:
23 November 2019
Accepted:
2 January 2020
Published:
9 January 2020
Abstract: Diabetes mellitus is one of the most common diseases of the endocrine system that is encountered in the practice of any doctor in any specialty. Some features of type 2 diabetes are: a slow progressive development and a mild clinical picture in the early stages of the development of the disease. The main goal of diabetes treatment is to prevent the development of late complications that reduce the quality of life of patients, leading to their early disability and death. Despite the increase in the number of antihyperglycemic drugs in the pharmaceutical industry, we are still not successful enough to achieve good glycemic control. In addition, achieving good glycemic control does not always prevent macrovascular complications in patients with diabetes mellitus. The article presents the results of two studies. The first study examined the diurnal fluctuations in blood glucose levels during therapy with type 4 dipeptidyl peptidase inhibitor Sitagliptin, as well as its effect on oxidative stress markers in comparison with MV gliclazide. The second study examined the role of sitagliptin in the correction of disorders of fat metabolism.
Abstract: Diabetes mellitus is one of the most common diseases of the endocrine system that is encountered in the practice of any doctor in any specialty. Some features of type 2 diabetes are: a slow progressive development and a mild clinical picture in the early stages of the development of the disease. The main goal of diabetes treatment is to prevent the...
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Effect of Risk Management in Diabetic Retinopathy
Junnan Lin,
Ye Li,
Lishi Luo
Issue:
Volume 5, Issue 1, March 2020
Pages:
6-8
Received:
28 December 2019
Accepted:
6 January 2020
Published:
21 January 2020
Abstract: Objective: To evaluate the effect of risk management of nursing in diabetic retinopathy patient. Methods: 98 patients diagnosed as diabetic retinopathy from January 2018 to January 2019, they were randomly assigned to control group and intervention group, we use the different nursing measure to both of groups. Our researchers collected the data of negative patient reaction and result of serum inflammatory cytokines in before treatment and after treatment. Additionally, we collected the information associated with quality of life on participants by the short form-36 (SF-36). Result: The results of intervention group were better than the results of control group in negative patient reaction [n (%), 1 (2.0%) vs 6 (12.2%), p < 0.005]. In addition, the serum inflammatory cytokines and quality of life were improved after treatment, the improvements of intervention group were better than outcome of control group, most result of them had statistical significance (p < 0.005). Conclusion: The risk management of nursing improved the outcome of diabetic retinopathy treatment. Although improvement of negative patient reaction was non-significant in result, other aspect of patient had significantly improvement which were serum inflammatory cytokines and quality of life.
Abstract: Objective: To evaluate the effect of risk management of nursing in diabetic retinopathy patient. Methods: 98 patients diagnosed as diabetic retinopathy from January 2018 to January 2019, they were randomly assigned to control group and intervention group, we use the different nursing measure to both of groups. Our researchers collected the data of ...
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Analysis of Hypoglycemic Episodes in Out Patient Diabetic in Africans Using Ademolus Classification of Hypoglycemia
Adegbenga Bolanle Ademolu
Issue:
Volume 5, Issue 1, March 2020
Pages:
9-17
Received:
23 February 2020
Accepted:
24 March 2020
Published:
14 April 2020
Abstract: The recent grading of severity of hypoglycemia for use in clinical practice using Ademolus Classification of Hypoglycemia (ACH) is opening a new knowledge path and insight in hypoglycemia complicating diabetes mellitus management. In Africa like other parts of the world, hypoglycemia complicates diabetes mellitus management in in and out-patients. This article aims to examine hypoglycemia occurring in African diabetics on out patient pharmacologic management. This is a retrospective study of 200 hypoglycemic episodes occurring in 88 diabetics attending the out patients of the Endocrinology Clinic of Lagos State University Teaching Hospital, Lagos, Nigeria. Over 13years and 9 months period. Data were analysed using ADEMOLUS CLASSIFICATION OF HYPOGLYCEMIA and American Diabetes Association (ADA)/European Association for the Study of Diabetes (EASD) 2018 Classification of Hypoglycemia. Only documented hypoglycemic episodes were studied using a questionnaire. The inclusion criteria includes known diabetics, documented hypoglycemic episodes occurring during out patient pharmacologic management. This study was analysed using SPSS version 17. Of the 200 hypoglycemic episodes studied, 79.5% were grade 1, grade 2 were 18% while 2.5% were grade 3. In all type 2 diabetics (T2DM), 82.9% had grade 1 hypoglycemia, 14.6% had grade 2, while 2.4% had grade 3. The lowest hypoglycemic episode among out patient T2DM was an asymptomatic value of 29mg/dl (grade 3 hypoglycemia!). There is an inverse relationship between hypoglycemic episodes recorded in type 1 and type 2 diabetics as the pearson correlation was -1.000. This denotes a perfect negative correlation between hypoglycemic episodes developed in type 1 compared to type 2 diabetics in Africans. There is no linear relationship between these two variables. With a p-value of 0.000, the null hypothesis is discarded in this study as these findings is not due to chance or error of sampling but rather are statistically significant. ADA/EASD 2018 classification of hypoglycemia is not very sensitive in diagnosing severe hypoglycemia in that it recognized only 1 hypoglycemic episodes while ACH recognizes five. The five cases all have blood sugar of less than 40mg/dl yet ADA/EASD 2018 classification recognizes only one because it developed a severe event from hypoglycemia needing assistance from a third party. The majority of T2DM had mild hypoglycemic episodes irrespective of whether they are on oral hypoglycemic agents (OHA) alone, or on OHA and insulin or on insulin alone. Among African T1DM, grade 1 hypoglycemia is twice as common as grade 2 hypoglycemia while severe hypoglycemia is not common. Grades 1, 2 and 3 hypoglycemia can all occur in African diabetics on out patients basis but with the majority occurring as grade 1. Asymptomatic grade 3 hypoglycemia can occur in out patient African T2DM. A similar study is advised in other regions of the world.
Abstract: The recent grading of severity of hypoglycemia for use in clinical practice using Ademolus Classification of Hypoglycemia (ACH) is opening a new knowledge path and insight in hypoglycemia complicating diabetes mellitus management. In Africa like other parts of the world, hypoglycemia complicates diabetes mellitus management in in and out-patients. ...
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